Trimetazidine, known as TMZ, is a drug used to treat angina and other heart-related conditions. It works by increasing blood flow to the heart and limiting rapid swings in blood pressure. The drug is not approved for use in the United States.
Why was trimetazidine banned?
It is listed in the World Anti-Doping Agency’s (WADA) 2021 prohibited substances under the category of “hormone and metabolic modulators,” a class of drugs that have been banned by WADA due to evidence of athletes using them for performance enhancement.
What is the benefit of taking trimetazidine?
It is used to prevent and treat the symptoms of angina (chest pain). Angina is caused by lack of blood supply and oxygen to your heart. Trimetazidine helps to maintain the energy metabolism of heart muscle cells, protecting them from the effects of reduced oxygen supply.
Why did Russian skater take trimetazidine?
WADA categorizes it as a “hormone and metabolic modulator,” making it illegal for athletes in and out of competition. “If you increase the blood flow to the heart, you could potentially increase the performance of the heart, which may in turn enhance the performance of an athlete,” DePasquale explained.
How does trimetazidine help the heart?
Trimetazidine (TMZ) is a medication used to treat heart-related conditions like angina. It helps metabolize fatty acids, which helps your body use oxygen. The drug allows for more blood flow to your heart and limits quick changes in your blood pressure. This can help lessen chest pain from blocked blood vessels.
Why is trimetazidine not available in USA?
In a PET study, trimetazidine modestly decreased myocardial fatty acid oxidation without changing overall oxygen consumption, implying but not proving an increase in glucose oxidation. However, trimetazidine has limited availability and is not FDA approved for use in the United States.
Is trimetazidine banned in the usa?
The US Food and Drug Administration has not approved TMZ for use in the US. Around 700 sports organizations have signed the world anti-doping code, which is managed by the World Anti-Doping Agency, WADA. Since 2014, WADA has classed TMZ as a prohibited substance.
What drugs should not be taken with trimetazidine?
Drug-Drug Interactions: TRIMETAZIDINE interacts with TRIMETAZIDINE, so it should be used with caution with sedatives or hypnotics (buspirone), strong painkillers, some allergy medications (chlorphenamine), certain antidepressants (fluoxetine and lithium), medicines to lower blood pressure (methyldopa), medicines to
How long does trimetazidine stay in your body?
026-0.67%. In young, healthy subjects, the half life of trimetazidine is 7.81 hours. In patients over 65, the half life increases to 11.7 hours.
What happen if you stop taking trimetazidine?
Do not stop taking your medication without checking with your healthcare professional. If you stop taking your medication, you may experience a worsening of your condition. This medicine should be taken with or after food.
Does trimetazidine improve performance?
While it does not have the muscle building or stimulant-like effects of many commonly recognized performance-enhancing or doping drugs, trimetazidine may enhance athletes’ physical efficiency and endurance.
Why are they letting Kamila compete?
In its report, the court panel said it had decided that Valieva could continue skating at the Olympics because she was not to blame for the delay in providing a conclusive result by the Stockholm laboratory that analyzed her sample. That result came after Valieva had already skated in Beijing.
Is trimetazidine a controlled substance?
It is an anti-ischemic (antianginal) metabolic agent of the fatty acid oxidation inhibitor class, meaning that it improves myocardial glucose utilization through inhibition of fatty acid metabolism.
Trimetazidine.
| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | C01EB15 (WHO) |
| Legal status | |
| Legal status | UK : Controlled Drug |
What kind of medicine is trimetazidine?
Trimetazidine is a cytoprotective drug that normalizes metabolic disturbances in low-flow ischemia via several—not yet fully understood—mechanisms of action. The best known trimetazidine mechanism of action is its capacity to inhibit β-oxidation of free fatty acid (FFA) [1].
Is trimetazidine a beta blocker?
Despite efficacy being equivalent to that of beta-blockers and calcium antagonists, trimetazidine does not depress cardiac function and, correspondingly, is not contraindicated in any condition. Adverse effects of trimetazidine are mild and infrequent.
How does trimetazidine increase blood flow to the heart?
We propose that trimetazidine acts by reducing fatty acid oxidation, thereby increasing glucose oxidation before and during the ischemic event. This altered metabolic balance will improve the capacity of the ischemic heart to balance the dramatic increase in glycolytic flux with an increase in glucose oxidation.
What is another name for trimetazidine?
Trimetazidine dihydrochloride
| PubChem CID | 83201 |
|---|---|
| Structure | Find Similar Structures |
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C14H24Cl2N2O3 |
| Synonyms | Trimetazidine dihydrochloride 13171-25-0 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride Trimetazidine hydrochloride Kyurinett More… |
Who invented trimetazidine?
Trimetazidine is an anti-ischaemic agent being developed by Servier for the treatment of angina pectoris,eye disorders, ischaemic heart disorders, tinnitus and vertigo.
Does trimetazidine give you energy?
Trimetazidine has been on the World Anti-Doping Agency’s list of banned substances since 2014. Unlike some other banned substances, trimetazidine does not give users an immediate boost in physical strength and energy.
Why do athletes take TMZ?
It’s believed that TMZ can improve physical efficiency, especially in the case of endurance sports, although opinions vary on how long-lasting the effect could be. It’s a drug that’s usually taken once or twice a day, and easy to detect in tests as a synthetic drug.
What is the best time to take trimetazidine?
The dose is one tablet of 20mg or 1 ml (20 drops) of oral drop solution of trimetazidine three times a day during meals. The dose is one tablet of 35mg of trimetazidine twice daily during meals.